05.15.08

Loss of balance in old age and brain changes

Posted in Aging at 4:40 pm by admin

Age-related white matter brain changes, also called leukoaraiosis, are frequently seen in older people and differ in severity, and the new study suggests that they are associated with gait and balance disturbances. Neurologists, geriatricians and family doctors often send older patients for brain scans to rule out severe brain atrophy (wasting), a tumor, stroke or brain infection because of mild mental difficulties, unsteadiness or depressed mood, and get back white matter changes as the main finding, Dr. Hansjoerg Baezner told Reuters Health.

University of Heidelberg in Mannheim, Germany, studied the impact of age-related white matter changes on functional decline in 639 men and women between the ages of 65 and 84 who underwent brain scans as well as walking and balance tests. Of the group, 284 had mild age-related white matter changes, 197 moderate changes, and 158 severe changes. They found that people with severe white matter changes were twice as likely to score poorly on tests of walking and balance as those with mild white matter changes. They further found that people with severe changes were twice as likely as the mild group to have a history of falls. The moderate group was one-and-a-half times as likely as the mild group to have a history of falls.

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So don’t just sit back and let old age happen to you. By following a regimen, you can slow down and even reverse aging.

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04.19.08

Elderly patients and problems after surgery

Posted in Aging, Provacyl Review at 2:15 am by admin

The study found that elderly patients who developed these postoperative cognitive problems were more likely to die in the first year after surgery. Patients over the age of 60 who have elective surgeries such as joint replacements, hysterectomies and other non-emergency, inpatient procedures, are at an increased risk for long-term cognitive problems, according to a new study led by Duke University Medical Center researchers.

The researchers measured memory and the ability to process information in more than 1000 adult patients of different ages. Patients were tested preoperatively, at the time of hospital discharge, and three months after surgery. More than 200 control subjects took the same tests at the same frequency, but did not undergo surgery or anesthesia. The researchers published their findings in the January 1, 2008 issue of the journal Anesthesiology and the results were published early online on December 27, 2007 on the journal’s Web site. The article is accompanied by a supportive editorial and a companion article detailing the types of cognitive dysfunction that developed and the effects on patients’ daily lives. The study was funded by the National Institute on Aging, the Anesthesia Patient Safety Foundation and the I. Heerman Foundation.

The study found that many of the young, middle-aged and elderly patients experienced postoperative cognitive dysfunction (POCD) at the time they left the hospital. But three months later, those aged 60 and older were more than twice as likely to exhibit POCD. Those with POCD at both the time of hospital discharge and three months after surgery also were more likely to die within the first year after surgery.

Studies on normal aging have shown a link between abrupt cognitive decline and early death, so we speculated that surgery-related cognitive dysfunction might have the same effect.

Why some patients suffer POCD is not known, but one hypothesis is that surgery and the accompanying anesthesia might cause inflammation in the brain that can affect the patient’s ability to learn, retain or remember information. Now that the implications of long-term POCD are better understood, doctors must devise strategies to prevent or mitigate the detrimental effects of surgery and anesthesia on the aging brain. The types of interventions and how to implement them will be the subject of further research.
Provacyl® is a supplement made from quality ingredients, made to promote your body’s natural testosterone. Provacyl will restore your physical and mental condition. This new natural medicine is capable to exempt you from stress and depression. Because it’s a supplement and not a medication, you don’t need a prescription and it’s free of any side effects. You’ve undoubtedly heard of how good ginkgo biloba is for you, rejuvenating your blood flow and improving sexual function, or that Brazil’s acai fruit is a great antioxidant. These are just a few of the herbal ingredients. On top of these though, Provacyl also combines Dehydroepiandrosterone (DHEA), which converts into testosterone and other sex hormones, and Growth Hormone (GH), which has been applauded by medical researchers as the fountain of youth.

So don’t just sit back and let old age happen to you. By following a regimen, you can slow down and even reverse aging.

__________________________________________________________

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Gene responsible for the onset of aging

Posted in Aging at 2:11 am by admin

Mayo Clinic researchers have discovered a gene responsible for the onset of aging, including age-related disorders such as infertility, reproductive problems and cataracts.

This research, conducted in genetically modified mice, is promising in helping physicians understand and treat the same disorders in humans.

“Darren Baker in our laboratory found that mutant mice with low amounts of BubR1 protein live five times shorter than normal mice. They also develop a variety of age-related disorders at a very young age,” says lead investigator Jan van Deursen, Ph.D., of the Mayo Clinic Departments of Pediatric and Adolescent Medicine, and Biochemistry and Molecular Biology.

Another Mayo investigator, Karthik Jeganathan, discovered that mice with low amounts of BubR1 protein are infertile and unable to distribute chromosomes properly when their germ cells divide. Abnormal numbers of chromosomes in germ cells are a hallmark of reproductive aging in humans, and the primary cause of increased still births and birth defects, such as Down syndrome, in women over 35 years of age. Says Dr. van Deursen, “Given the age-dependent decline in ovarian BubR1 in mice, it seems reasonable to assume that this protein may contribute to age-related infertility and certain birth defects in humans.”

Dr. van Deursen says, “This prompted us to investigate whether BubR1 protein levels go down as normal mice age naturally — which is indeed what we found. Based on these findings, we believe it is the decline of this protein with time that may trigger some of the physiological effects of aging.”

Provacyl® is a supplement made from quality ingredients, made to promote your body’s natural testosterone. Provacyl will restore your physical and mental condition. This new natural medicine is capable to exempt you from stress and depression. Because it’s a supplement and not a medication, you don’t need a prescription and it’s free of any side effects. You’ve undoubtedly heard of how good ginkgo biloba is for you, rejuvenating your blood flow and improving sexual function, or that Brazil’s acai fruit is a great antioxidant. These are just a few of the herbal ingredients. On top of these though, Provacyl also combines Dehydroepiandrosterone (DHEA), which converts into testosterone and other sex hormones, and Growth Hormone (GH), which has been applauded by medical researchers as the fountain of youth.

So don’t just sit back and let old age happen to you. By following a regimen, you can slow down and even reverse aging.

__________________________________________________________

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Aging human brain and genetic signature

Posted in Aging at 2:08 am by admin

One of the study’s more surprising results was that these gene changes start in the 40s for some individuals. The results raise intriguing questions about when and why the brain begins to age and the possibility of developing strategies to protect critical genes early in life in an attempt to preserve brain function and delay the onset of age-related conditions such as Alzheimer’s disease.

To investigate age-associated molecular changes in the human brain, Dr. Bruce A. Yankner, professor in the Department of Neurology and Division of Neuroscience at Children’s Hospital Boston and Harvard Medical School, and colleagues examined patterns of gene expression in postmortem samples collected from thirty individuals ranging in age from 26 to 106 years.

Using a sophisticated screening technique called transcriptional profiling that evaluates thousands of genes at a time, the researchers identified two groups of genes with significantly altered expression levels in the brains of older individuals. A gene’s expression level is an indicator of whether or not the gene is functioning properly. “We found that genes that play a role in learning and memory were among those most significantly reduced in the aging human cortex,” said Yankner. “These include genes that are required for communication between neurons.”

The researchers then went on to show that many of the genes with altered expression in the brain were badly damaged and could not function properly. They showed that these genes also could be selectively damaged in brain cells grown in the laboratory, thereby mimicking some of the changes of the aging brain. In addition to a reduction in genes important for cognitive function, there was an elevated expression of genes that are associated with stress and repair mechanisms and genes linked to inflammation and immune responses. This is evidence that pathological events may be occurring in the aging brain, possibly related to gene damage.

If you examine brain gene patterns among young adults, they are quite similar. In very old adults, there is some increased variability, but there is still similarity between individuals. In contrast, individuals in the middle age population between 40 and 70 years of age are much more variable. Some middle-aged individuals exhibit gene patterns that look more like the young group, whereas others show gene patterns that look more like the old group. This is evidence that people may age differently during middle age. It will now be of great interest to understand what it is that makes some people age more rapidly than others.

These findings raise the exciting possibility that treatments or lifestyles that reduce gene damage in young adults may delay cognitive decline and the onset of brain diseases in later years. However, more research is needed. We can repair these aging genes in the laboratory, but that is a far cry from the human brain. This is only a first step.

Future directions of Dr. Yankner’s lab include investigating whether these changes of normal aging are responsible for age-related conditions such as Alzheimer’s and Parkinson’s disease in some individuals. A major goal is the development of therapeutic approaches to preventing gene damage in the brain that could conceivably preserve cognitive function and prevent or delay the onset of neurodegenerative diseases. Along these lines, his lab is also interested in determining whether gene damage in the brain can be reversed after it occurs.

Provacyl® is a supplement made from quality ingredients, made to promote your body’s natural testosterone. Provacyl will restore your physical and mental condition. This new natural medicine is capable to exempt you from stress and depression. Because it’s a supplement and not a medication, you don’t need a prescription and it’s free of any side effects. You’ve undoubtedly heard of how good ginkgo biloba is for you, rejuvenating your blood flow and improving sexual function, or that Brazil’s acai fruit is a great antioxidant. These are just a few of the herbal ingredients. On top of these though, Provacyl also combines Dehydroepiandrosterone (DHEA), which converts into testosterone and other sex hormones, and Growth Hormone (GH), which has been applauded by medical researchers as the fountain of youth.

So don’t just sit back and let old age happen to you. By following a regimen, you can slow down and even reverse aging.

__________________________________________________________

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04.16.08

Higher Testosterone Levels in Older Men

Posted in Aging, Men's Health at 9:38 pm by admin

With age, all the characteristics of body including mental functions change. Aging makes new learning slower and also new information is processed less carefully, and details often slip. A new research has suggested that testosterone levels might help improve men’s cognitive performance. Such changes give rise to the “senior moment” in healthy elders and to cognitive impairment and dementia in others.

The finding raises the question of whether testosterone therapy might help in improving mental function in healthy older men, or even in those with cognitive impairment. Some small studies have reported subtle improvements on cognitive tests. However, high testosterone levels may have harmful effects as well.

Likewise, testosterone levels also decline with age. According to the journal Harvard Men’s Health Watch falling hormone levels might account for some problem. The data is far from conclusive, but studies have found some connections. For instance, higher testosterone levels in midlife have been linked to better preservation of tissue in some parts of the brain. And, higher testosterone levels in older men have been linked with better performance on cognitive tests.

Provacyl® is a supplement made from quality ingredients, made to promote your body’s natural testosterone. Provacyl will restore your physical and mental condition. This new natural medicine is capable to exempt you from stress and depression. Because it’s a supplement and not a medication, you don’t need a prescription and it’s free of any side effects. You’ve undoubtedly heard of how good ginkgo biloba is for you, rejuvenating your blood flow and improving sexual function, or that Brazil’s acai fruit is a great antioxidant. These are just a few of the herbal ingredients. On top of these though, Provacyl also combines Dehydroepiandrosterone (DHEA), which converts into testosterone and other sex hormones, and Growth Hormone (GH), which has been applauded by medical researchers as the fountain of youth.

So don’t just sit back and let old age happen to you. By following a regimen, you can slow down and even reverse aging.

__________________________________________________________

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